Cannabinoids Explained (Part 2): CBD-A (CBD-ACID)

We continue our Cannabinoids Explained series with another compound that exists in the Cannabis sativa plant and seems to exert important therapeutic effects:  cannabidiol CBD-a.

Cannabidiol CBD-a or CBD-acid is the main form in which cannabidiol CBD exists in the cannabis plant, along with THC-a (THC-acid). whole plant extract with naturally occurring cannabidiol CBD is obtained through non-enzymatic decarboxylation from the acidic form of the cannabinoid, this reaction taking place when the compounds are heated.

The decarboxylation procedure is also called “activation”, and requires about 90 minutes when the cannabis infusions are heated at 212° F.

Heating the plant at a lower temperature or for a shorter time may lead to partial instead of full activation; until recently, it’s been considered that this is not desirable or convenient, as it reduces the final amount of naturally occuring cannabidiol CBD obtained from a plant. However, new research suggests that cannabidiol CBD-a may also be of great value for humans.

When this compound was first discovered, it was thought to be a minor cannabinoid, and most producers preferred to decarboxylate cannabidiol CBD-a so as to obtain higher amounts of whole plant extract of naturally occuring cannabidiol CBD. Yet, the existing studies are promising, as the acidic form of cannabidiol seems to have anti-inflammatory and anti-proliferative effects, helping in the prevention of inflammation and bacterial infections.

What studies say about cannabidiol CBD-a

Just like whole plant extract with naturally occurring cannabidiol CBD, cannabidiol CBD-a is a non-psychoactive compound, so it does not cause one to get high if present in whole plant extract with naturally occuring cannabidiol CBD products. This compound is currently investigated for the following applications:

  • Inhibition of bacterial growth – the potential anti-bacterial effect of cannabidiol CBD-a is supported by a study published in 2000, conducted by researchers at the Biotech Center, Rutgers University, NJ. The study (“The composition of hemp seed oil and its potential as an important source of nutrition”) highlights the correlation between the levels of cannabidiol CBD-a and the antimicrobial potency of the resulting cannabidiol CBD. According to this paper, a higher concentration of acid cannabidiol will result in a greater antibacterial potency of the final whole plant extract with naturally occurring CBD product.
  • Reduction of inflammatory processes – the anti-inflammatory effect of  cannabidiol CBD-acid seems to be the result of the inhibitory action of this compound on COX-2 (cyclooxygenase-2), compound involved in inflammatory processes and in the metastasis of cancer cells.
  • Reduces nausea and vomiting – the anti-emetic effect of cannabidiol CBD-a is supported by two different studies, first one showing that this compound reduces vomiting and nausea by increasing the activity at the 5-HT1A receptor, and the second one showing that cannabidiol CBD-a can function as an anti-emetic agent, without the involvement of CB receptors.
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