How Cannabidiol Works in the Human Body
September 8, 2020
Unveiling the Endocannabinoid System and Its Interaction with CBD
The presence of the Endocannabinoid System is not limited to just humans but also encompasses in all mammals and invertebrates. humans and encompasses all mammals and invertebrates. It’s quite fascinating to consider its widespread existence. Were you previously aware of its existence? Like many of us, it is likely a recent or entirely newfound revelation. The system of the endocannabinoid (ECS) has been well-known to scientists since 1992. It was only because of the recent surge in the use of Cannabidiol CBD that the public was first introduced to the advantages of CBD.
It is essential to remember that our understanding of Cannabidiol and its impact. There are many aspects of this intricate system that are not fully comprehended. While CBD holds potential as a promising treatment agent, further research is necessary to determine the precise mechanisms involved and explore its potential applications.
What makes the ECS vital, and what function does CBD have to play in this?
Continue reading as we delve into the answers.
How did the Endocannabinoid System Get its Name?
1964
The development that the Endocannabinoid System can be traced back to the cannabis plant. Professors Yechiel Gaoni and Raphael Mechoulam were the first to report the identification and isolation of the psychoactive component THC from cannabis. Drawing inspiration from the word cannabis, they coined the term “cannabinoid” to describe this compound.
1988
In a significant breakthrough, Professor Allyn Howlett and Researcher William Devane discovered receptor sites in the brain that respond to cannabis. These receptors were specifically sensitive to cannabinoids present in cannabis sativa, leading to their aptly named designation as cannabinoid receptors.
1992
Working alongside William Devane, Analytical Chemist Lumir Hanus isolated the first known endocannabinoid in the human brain. This discovery confirmed the existence of a biological system necessary for regulating this endogenous cannabinoid.
Thus, the Endogenous Cannabinoid System was established, with “endogenous” referring to its growth or origin within an organism. Over time, the term was shortened to Endocannabinoid System, which is widely accepted today. The prefix “endo” now represents the concept of endogenous.
What are Endocannabinoids?
Endocannabinoids are neurotransmitters and can bind to specific receptors found within the brain. They play a crucial role in maintaining homeostasis, the balance of internal processes within the body, by facilitating proper functioning.
The distribution of receptors for endocannabinoids spans various parts of the body, including organs, the brain, and immune cells, indicating their wide-ranging presence. Understanding the connection between endocannabinoids and their receptors is crucial to understand the impact that Cannabidiol CBD for the human body.
Exploring the extensive distribution of endocannabinoids and their receptors opens up avenues for valuable insights into our physiological processes through continued research in this field.
Is CBD Already in Your Body?
An endogenous form of Cannabidiol CBD already exists in our bodies. CBD is classified as a phytocannabinoid because it originates from plants. Our bodies naturally produce endocannabinoids, which are cannabinoids produced internally. While we don’t technically produce CBD, our bodies do produce another type of cannabinoid that CBD mimics. Just as our internal endocannabinoids interact with the Endocannabinoid System (ECS), the introduction of CBD stimulates our ECS into action.
While CBD holds promise as a natural compound with potential health benefits, each individual’s circumstances and health profile are unique. Healthcare professionals can provide personalized guidance and recommendations based on your specific needs and medical history. They can help assess potential risks, evaluate appropriate dosage, and ensure CBD usage aligns with your overall healthcare plan.
By seeking professional advice, you can make informed decisions regarding the use of CBD and explore its potential benefits while prioritizing your health and well-being.
THC and CBD: Similar Yet Different Cannabinoids
THC and Cannabidiol CBD are both cannabinoids, but they differ in their origin and how the body processes them. In reality, they are only two of the 113 identified cannabinoids, and each of them interacts with our cannabinoid receptors in a distinctive manner.
THC is a constituent of marijuana, a specific variety of cannabis sativa known for its euphoric effects. Marijuana has a high THC content and low CBD content. On the other hand, hemp refers to cannabis sativa varieties bred to contain less than 0.03% THC while still having a high ratio of cannabinoids, including CBD. CBD extracted from hemp may contain trace amounts of THC but does not induce the “high” experienced by marijuana users. This distinction arises from the different ways in which each phytocompound communicates with our receptors.
What Does CBD Do to the Endocannabinoid System?
Following was introduction of Full Spectrum CBD into the body, there is a belief to be the case that it is believed that the Endocannabinoid System (ECS) is stimulated by stimulating CB1 and CB2 receptors. However, CB1 receptors are found primarily in the brain. CB2 receptors are located within the immune system. When Cannabidiol CBD, the chemical drug (CBD) is introduced into your system, it activates CB1 receptors in the brain and gut.
CB1 receptors are proteins that bind to endocannabinoid molecules. By adhering to the molecules the receptors do not just detect CBD’s presence CBD but also control the flow of messages to the brain. They also influence different brain reactions like appetite, mood, memory, and pain.
Many cannabinoids are found in Cannabis Sativa. plants. Full Spectrum CBD contains a number of other cannabinoid compounds and terpenes. They may interact to create the overall effect of Full Spectrum CBD, a phenomenon referred to as the entourage effect.
Are There Any Negative Side Effects of CBD?
Neurosciencenews.com reports that an increase in endocannabinoid levels in the brains of mice has been discovered to lead to inflammation of the cerebellum. Please note that no comparable side effects have been observed in humans. In this study, researchers used degradation inhibitors which caused endocannabinoids to over-accumulate in the brain. While the results appear to be concerning, they were not obtained by administering any phytocannabinoid, including CBD. They were observed only when manipulating the body’s own endocannabinoids in an experiment conducted using only mice.
A vast amount of research on Cannabidiol CBD is a well-studied phytocannabinoid that has proven its security and low side negative effects on human beings. Research studies, clinical research as well as real-life experiences have created the growing evidence that supports the well-tolerated and safe use of CBD for various therapeutic purposes.
Conclusion
The therapeutic possibilities of Cannabidiol CBD are extensive with promising research that suggests the effectiveness of CBD in easing symptoms of a myriad of ailments such as chronic anxiety, inflammation, pain, and epilepsy. Furthermore CBD’s non-toxic qualities and its high security rating make it a top choice to those who are looking for alternative therapies.
In the last five decades since the initial discovery of cannabinoids, our comprehension of the impact of CBD on the endogenous Endocannabinoid System has made substantial advancements. With the growing demand for CBD products, there is an increasing need for scientific research to delve into the intricate physiological interplay of our ECS and specifically how CBD can optimize various biological systems.
Currently, we know that CBD mimics our own endocannabinoids to engage the ECS, which is a complex system responsible for maintaining bodily homeostasis. As stated by Bradley E. Alger, Ph.D., a Harvard University graduate and neuroscience specialist, “endocannabinoids are literally a bridge between body and mind.”
